Tittle: Optimal Group Sequential Design.

Speaker: Dr. An Qi
Time: 2018年05月10日16:00-17:00

Location: Center for Mathematical Sciences, Room 813

Abstract:
A group sequential design is referred to an optimal one if the expected sample size under specified alternative is minimized for a given choice of significance level and power among tests with a given sequence of groups of specific sizes. Optimal two-sided tests with acceptance region of the null hypothesis at early stages with and without known variance is discussed. A method of simulation is proposed to compute optimal group sequential tests that minimize the average sample size and meet significance level and power requirements. Optimal designs can be used in clinical trials directly, and provide a standard for assessing the efficiency of other designs as well. The proposed method is conceptually simple and straightforward.