Title：Multi-stage and multi-scale models in HIV infection and treatment

Speaker:  Libin Rong (University of Florida)
Time：2018年5月22日16:30-17:30
Location：Center for Mathematical Sciences, Room 813
Abstract：

Highly active antiretroviral therapy has successfully controlled HIV replication in many patients. The treatment effectiveness depends on many factors, such as the intracellular stages of the viral replication cycle inhibited by drugs and drugs' pharmacodynamics. In this talk, I will present some recent work on studying HIV dynamics under treatment. Using multi-stage models, we will show that different drug classes have different influence on HIV decay dynamics. Using multi-scale models, we will show that pharmacodynamic characteristics of drugs and the dosing schedule can significantly affect the outcome of either early or late treatment.